Vitamin-D status and neurodevelopment and growth in young north Indian children: a secondary data analysis
نویسندگان
چکیده
BACKGROUND Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children. METHODS We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India. We measured vitamin-D status and neurodevelopment by the Ages and Stages Questionnaire-3 (ASQ-3) at 12 to 36 months of age. Multiple logistic and linear regressions were used to examine the association between vitamin-D deficiency at baseline and neurodevelopment and growth 6 months follow-up. RESULTS 25-hydroxy-vitamin-D (25OHD) concentration was measured at baseline for 960 (96%) children. Of these, 331 (34.5%) children were vitamin-D deficient. The total and subscale (except for the Personal social scale) ASQ-3 scores, were not different between the vitamin-D deficient and non-deficient children. Vitamin-D deficiency was also not associated with physical growth at baseline and at follow -up. CONCLUSION Our data do not support the hypothesis that vitamin-D deficiency is associated with poor growth and neurodevelopment. TRIAL REGISTRATION NCT00717730 and CTRI/2010/091/001090 . Date of registration: 08 October, 2010.
منابع مشابه
Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis
BACKGROUND Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this paper, we examined the extent to which vitamin-D deficiency (<10 ng/ml) predicts ALRI, clinical pneumonia and dia...
متن کاملThe Epidemic of Poor Vitamin D Status among 9-12 Years Old Children in Tehran, 2008, Using HPLC: Need for an Urgent Action
Background and Objectives: Vitamin D deficiency/insufficiency is a global health problem. The importance of this problem is doubled in growing children because of their increased need for skeletal growth. This investigation was performed firstly to assess vitamin D status, and secondly to examine its possible relationship with sex, residing area and duration of sun exposure in 9-12 years old ch...
متن کاملCompare of the Effect of Exercise Training in Different Places on the Serum Vitamin D Levels of Young Women
Background: vitamin D insufficiency/deficiency is serious concern among young women. The maintain of an adequate vitamin D status, which can impact on health and exercise performance, is important to athletes and non-athletes. The aim of this study was to compare of the effect of exercise training in in outdoor and indoor places on the serum vitamin D levels of young women. Methods: In this qua...
متن کاملEffects of Vitamin D in Neonates and Young Infants
Vitamin D is important for the development, growth, and mineralization of the skeletal in neonates and children. Vitamin D is essential for intestinal absorption of calcium. Vitamin D is metabolized to 25-hydroxyvitamin D and then to 1,25-dihydroxyvitamin D. Pregnant women in developed countries often have insufficient serum concentrations of 25-hydroxyvitamin D and a supplementation of vitamin...
متن کاملVitamin D deficiency and secondary hyperparathyroidism in pediatrics obesity
Obesity is one of the health problems in the developing and developed countries. Obesity subjects the individuals with metabolic and endocrine disorders. It is obvious that vitamin D deficiency or insufficiency may lead to secondary hyperparathyroidism. Thus, obesity increases the risk of vitamin D deficiency. Considering the high prevalence of vitamin D deficiency in children and adolescents w...
متن کامل